I've seen and am using a team based around lowering the opponent's stats and then sweeping with a single, stat-upped pokemon. These teams get pretty easily taken down if they don't have Roar or Whirlwind if the opponent puts down a substitute. So I felt it would be important for users of this strategy to be aware of the pokemon in the line who use Substitute and what else they know:
210 | Charizard | Adamant | Salac Berry | Dragon Claw | Flame Charge | Belly Drum | Substitute | HP/Spd/SpD
225 | Marowak | Careful | Salac Berry | Substitute | Detect | Earthquake | Swords Dance | HP/SpD
266 | Tauros | Naughty | Liechi Berry | Earthquake | Rock Slide | Endure | Substitute | Atk/Spd
271 | Scrafty | Naughty | Liechi Berry | Fake Out | Bulk Up | Focus Punch | Substitute | HP/Atk
387 | Meganium | Bold | Chesto Berry | GrassWhistle | Double Team | Substitute | Rest | HP/Def
407 | Breloom | Jolly | Toxic Orb | Substitute | Seed Bomb | Wake-Up Slap | Spore | Atk/Spd
429 | Lopunny | Jolly | Liechi Berry | Charm | Focus Punch | Substitute | ThunderPunch | Atk/Spd
452 | Toxicroak | Modest | Petaya Berry | Focus Blast | Sludge Bomb | Substitute | Protect | Spd/SpA
507 | Yanmega | Modest | Sitrus Berry | Psychic | Bug Buzz | Swagger | Substitute | HP/SpA
520 | Leafeon | Naive | Liechi Berry | Leaf Blade | Giga Impact | Substitute | Yawn | Atk/Spd
571 | Serperior | Calm | BrightPowder | Leaf Storm | Substitute | Hyper Beam | Toxic | HP/Def/SpD
621 | Scrafty | Adamant | Muscle Band | Substitute | Payback | Hi Jump Kick | Focus Punch | HP/Atk
646 | Poliwrath | Adamant | Leftovers | Waterfall | Focus Punch | Encore | Substitute | HP/Atk
665 | Shuckle | Relaxed | Lax Incense | Gyro Ball | Double Team | Substitute | Power Trick | HP/Def
734 | Venusaur | Bold | Black Sludge | Leech Seed | Substitute | Sludge Bomb | Protect | HP/SpD
735 | Charizard | Adamant | Salac Berry | Belly Drum | Substitute | Fire Punch | Earthquake | HP/Atk/Spd
739 | Feraligatr | Adamant | Liechi Berry | Dragon Dance | Waterfall | Crunch | Substitute | Atk/Spd
745 | Empoleon | Calm | Petaya Berry | Surf | Substitute | Blizzard | Whirlpool | HP/SpA
747 | Emboar | Timid | Salac Berry | Substitute | Flamethrower | Focus Blast | Scald | Spd/SpA
749 | Dugtrio | Jolly | BrightPowder | Toxic | Dig | Substitute | Sandstorm | Atk/Spd
757 | Breloom | Careful | Toxic Orb | Protect | Leech Seed | Substitute | Focus Punch | HP/Def/SpD
760 | Absol | Jolly | BrightPowder | Substitute | Swagger | Punishment | Will-O-Wisp | Atk/Spd
790 | Kangaskhan | Jolly | Salac Berry | Fake Out | Endeavor | Return | Substitute | Atk/Spd
792 | Spiritomb | Careful | Custap Berry | Will-O-Wisp | Sucker Punch | Substitute | Pain Split | HP/SpD
800 | Miltank | Jolly | Salac Berry | Substitute | Earthquake | Rock Slide | Zen Headbutt | Atk/Spd
803 | Gothitelle | Modest | BrightPowder | Substitute | Flatter | Psych Up | Psychic | HP/SpA
851 | Mandibuzz | Careful | Leftovers | Substitute | Swagger | Punishment | Roost | HP/Def/SpD
941 | Tornadus | Modest | Leftovers | Substitute | Double Team | Focus Blast | Hurricane | HP/SpA
958 | Cobalion | Jolly | Lax Incense | Swagger | Substitute | Psych Up | Iron Head | Atk/Spd
986 | Cresselia | Bold | BrightPowder | Psychic | Substitute | Toxic | Trick Room | HP/SpD
Some things to note:
-You don't face any Substitute users until #210 Charizard, so there aren't any of them in the normal line or in the Super line until fight #15.
-Charizard and Scrafty have more than one set with Substitute.
I'll edit in more later if it proves to be useful.
(Thanks to Team Rocket Elite for the list)
441 D/Cs and counting, baby!
*Contrary to popular belief, this is not a compendium of people who disconnect on Wi-Fi. See: Seinfeld, "The Comeback."