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Toxic Spikes does help a lot actually, more than all those other shit that was suggested by the man who does not know anything. However, a carefully planned substitute can ruin your plans. Smeargle, imo, changes the playing field completely.

Smeargle just needs some Speed passed onto it, a Shell Smash from something like Gorebyss is excellent if you can get a sub to pass over to Smeragle. It has decent enough defenses, and can Swift Swim. Now that the torch has been passed to Smeargle, he can then proceed to Spore, and set up a sub from there, and get to work on the Quiver Dances. At the worst case scenerio, he has +4 boosts when he jumps out, and +4 more to that if he gets a Quiver Dance in, making Stored Power a real doozy to anyone that does not resist it. If a T-tar comes in afterwards, BP all those wonderful boosts to someone else capable of dealing multiple threats, hmmm...!

Alternatively, T-Wave Support can be used in order to slow them down. Groudon is excellent candidate as a Supporter, for it can make Sun, the least popular choice for weather so there is no worry for SSwim that can outrun you, but more importantly, getting rid of the cursed sand that will threaten Smeargle's longevity and his role in the field.

Did we implement Sleep Clause into our uber ladder, since if we don't, you can see how stupid it is with a Smeargle like that.