I totally liked Sub Hydreigon in BW2 since it was a great counter to VolTurn; between Fire Blast/Rain boosted Surf(what I used)/dragon pulse/focus blast, it easily beat the annoying, omnipotent sand volturn.
Counters for this set are Chansey/Blissey as CSC mentioned, but a Jellicent with some SpDef investment also stalls out Hydreigon if you lack Roost
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