ok so this one has 100% success for me in picking up chicks, but it requires some preparation.
First off its going to require a certain situation, but if the situation is any good it works just as well for picking up random strangers as it does for chicks you already know or are just mildly acquainted with:
The idea here is to walk somewhere or be walking somewhere. And it will seem more natural if the weather is cold.
So, you need to walk really, really fast. As fast as you can trying to outpace her just slightly.
Now hopefully you aren't a slow fuck, in which case she'll be getting breathless trying to keep up (youre just trying to barely set a pace that is uncomfortable for her, but still comfortable for you).
Now 2 things will happen next. Either A) She will begin to get out of breath and/or B) She'll ask why youre walking so fast.
Look her in the eyes and say, "This isn't the only way I can get you breathless."
And then you kiss her.
This has worked 3 times for me. Twice with girls i knew but was not dating, and once with a random stranger (the kiss was really awkward, but I spent the night with her).
Just remember, picking up a girl is exactly like playing poker.
Both of you have thoughts about the other from talking or hanging out or whatever, thats your hand. Your actual opportunity to pick her up, with a line or with a kiss or whatever, thats the flop. You need to sort of get her off balance, your advance needs to be surprising enough that she doesn't have enough time to overanalyze it. She will only know whether shes is interested or disinterested and shell react that way.
YOURE POT COMMITTED ONCE YOU MAKE YOUR ADVANCE. But if she responds favorably, shes pot committed, and as long as you dont fuck up on the turn (which basically amounts to not forgetting her name in front of her friends and successfully getting her to a reasonably private spot) you can sleep together (thats the river).
The analogy gets shitty for the part that comes after you hit on her, but before that its so accurate. If you cant figure this out, youll be relying on girls to throw themselves at you "Oh my god youre fantastic for coming on to me, otherwise I would still be a virgin." <-dont be that guy (or do, whatever youre comfortable with).