Against Smeargle, you're supposed to attack on turn one, then switch to a spinner or a priority attacker. Or, if you see Smeargle on team preview, you don't lead with scolipede, you lead with someone who has Insomia or Lum Berry. As far as I'm concerned, most teams should have at least one pokemon with a lum berry on them for dealing the obvious obnoxious abundance of spore users. Works best if you've got priority or are simply very fast - Crobat's a great user of Lum Berry, for instance, and can gaunratee Smeargle won't do shit.
Scolipede suffers from similar issues to Ninjask - poor offensive coverage and mediocre defenses. I think it's misguided to try and use him as a baton passer lead, he's just way too damn predictable. Your opponent, if they have whirlwind or roar, will just bring that pokemon in, and undo all your stat boosting. Haze and Clear Smog are also pretty common, and then there's Topsy-Turvy to worry about now too...
If you're going to use Scolipede as a baton passer, you should save it for the mid game of the fight - preferably to augment a slow, physical mega pokemon like Charizard X, MMawile, MKhangaskhan, MPinsir, MScizor, or maybe MAmpharos. You get the idea. I think you really need to analyze your opponent before sending in someone like scoliopede, to find out what counters they might have to a baton pass strategy. People are pretty experienced from dealing with speed boost baton pass from dealing with Ninjask two generations ago.
Speedboost lead Scolipede definitely is better off as a physical attacker / hazard layer. If you don't see a spinner in team preview, get toxic spikes or spikes up. As a lead, I think you're best using...
Adamant, 252 Atk, 252 HP, 4 def
Earthquake
X-Scissor / Megahorn
Rock Slide / Swords Dance
Spikes / Toxic Spikes
I could potentially see him as being a good assault vest user, though, his coverage is kind of weak, he's fast enough, and got enough offensive power to be reasonably threatening.
I think his biggest Niche though, is this:
252 HP, some combination of 256 in SpD and Def
Infestation
Baton Pass
Swords Dance
Toxic Spikes / Protect / Iron Defense / Substitute
Get in, trap something good, get out with as many stat boosts as possible.
A pokemon like Scolipede is not greatly enhanced by black sludge / left overs, life orb, a choice item or even really focus sash. Stick with Lum Berry I think.
Actually, thinking it over some more, this is probably the most well rounded lead:
Lum Berry
252 HP
216 Atk or 216 Defense
40 Speed
Rock Slide
Earthquake / X-Scissor / Protect
Toxic Spikes / Swords Dance
Baton Pass
Take protect if you really covet passing speed boosts. Take X-scissor if you want high-damaging stab that's reliable. Always take Rock Slide, because a common switch in could easily be something like Talonflame, or hell, with how Defog works now, as a hazard user, you're going to need anti-flying.
As a speed boost user, you want to survive one turn. With 40 investment in speed though, you're gauranteed to outspeed non-scarf'd, non-mega pokemon on the beginning of the second turn. You'll outspeed almost anything on the third turn. In the case of Smeargle, you rock slide or X-Scissor it twice, negating the spore on turn one, then killing it outright on turn-two (they always have a focus sash). Other common leads like Skarmory are more annoying to deal with, as they could whirlwind your baton passes away - you should have a back-up lead in this case, or you should be willing to use someone with suction cups.
Take 216 in attack if your team needs someone quick with access to EQ, Rock Slide, or X-scissor. Take 216 in defense if you need a durable baton passer. Consider somebody else if you want to endure special attacks and baton pass stat boosts, I don't see that happening with Scolipede. One flamethrower and it's toast.