Mewtwo

Type Tier
Psychic Uber
Statistics
Stat
HP
106
415
Atk
110
318
Def
90
278
SpA
154
406
SpD
90
278
Spe
130
358
Name Item

Cursing Mewtwo

Leftovers
Moveset
~ Curse
~ Recover
~ Submission
~ Thunderbolt / Psychic / Fire Blast / Shadow Ball

Curse bolsters his Attack and cushions the Defense. Let loose with Submission. If they try to stop you with a physical wall or Ghost, counter it with the move of your choice. If you're playing the uber metagame, you'll probably want Thunderbolt. Shadow Ball is a possibility in the uber metagame too, but it leaves you kinda stuck against Skarmory and, to an extent, Lugia (since most of those have Curse). I know it seems like a crime not to use that 406 Special Attack, but in the uber metagame, Special Attacks aren't going to do a lot to the likes of Ho-oh and Lugia. You can Thunderbolt, but then you're stuck against Celebi. Unlike Mew, Mewtwo can't Swords Dance, so it can't go for the fast kill like Mew can.

Other Options

Mewtwo can Selfdestruct. There's Ice Beam to run from that Special Attack too. If you're scared of status effects (Sacred Fire burn), there's Rest. Mewtwo learns Thunder Wave, something that could be handy in the uber metagame if they don't have a Heal Beller.

Opinion

Mewtwo can't sweep fast, but it's good in the late game if you're using Ubers. It's not as good as it is in RBY, but it's still Uber to the max. You need to have Submission—otherwise Blissey, Snorlax, and Tyranitar are going to wall it.

Counters

Umbreon can Charm it, but it can't take too many Submission switch-ins. If you can paralyze it and get lucky, Heracross has a chance to take it out. If it doesn't have Submission, any of the special walls can usually stall it out—Blissey, Umbreon, and Snorlax.