Statistics
|
Stat |
| HP |
106
|
415 |
| Atk |
110
|
318 |
| Def |
90
|
278 |
| SpA |
154
|
406 |
| SpD |
90
|
278 |
| Spe |
130
|
358 |
Curse bolsters his Attack and cushions the Defense. Let loose with Submission. If they try to stop you with a physical wall or Ghost, counter it with the move of your choice. If you're playing the uber metagame, you'll probably want Thunderbolt. Shadow Ball is a possibility in the uber metagame too, but it leaves you kinda stuck against Skarmory and, to an extent, Lugia (since most of those have Curse). I know it seems like a crime not to use that 406 Special Attack, but in the uber metagame, Special Attacks aren't going to do a lot to the likes of Ho-oh and Lugia. You can Thunderbolt, but then you're stuck against Celebi. Unlike Mew, Mewtwo can't Swords Dance, so it can't go for the fast kill like Mew can.
Other Options
Mewtwo can Selfdestruct. There's Ice Beam to run from that Special Attack too. If you're scared of status effects (Sacred Fire burn), there's Rest. Mewtwo learns Thunder Wave, something that could be handy in the uber metagame if they don't have a Heal Beller.
Opinion
Mewtwo can't sweep fast, but it's good in the late game if you're using Ubers. It's not as good as it is in RBY, but it's still Uber to the max. You need to have Submission—otherwise Blissey, Snorlax, and Tyranitar are going to wall it.
Counters
Umbreon can Charm it, but it can't take too many Submission switch-ins. If you can paralyze it and get lucky, Heracross has a chance to take it out. If it doesn't have Submission, any of the special walls can usually stall it out—Blissey, Umbreon, and Snorlax.