Mixed Salamence is a staple on momentum-based offensive teams. Metagross and mixed Salamence make for a great physically defensive backbone on offensive teams, providing short-term defensive coverage without losing momentum. Metagross can chip walls such as defensive Swampert and Skarmory so that Salamence can more easily OHKO them. Likewise, Salamence can weaken these walls to give Metagross an easier time breaking through them. Note that Metagross's set choice is highly flexible and depends on the team's needs; Choice Band Metagross's Meteor Mash, mixed Metagross's Psychic, and even defensive Metagross's Toxic can heavily cripple Swampert or even defeat it with some luck, and all sets can use Explosion on Water-types. In particular, Choice Band Metagross's Meteor Mash has a high probability of breaking through Water-types with an Attack boost or a critical hit. Mixed Metagross can potentially pack Pursuit, which takes out Gengar after some chip damage from Salamence, or at least limits its ability to check Salamence. Agility Metagross variants especially enjoy Rock Slide Salamence removing Zapdos, Gyarados, and Moltres.
Since mixed Salamence dismantles physically defensive cores that incorporate Skarmory and Swampert, physical sweepers such as Dragon Dance Tyranitar and Aerodactyl pair well with it. Salac Berry Heracross is also a synergistic sweeper for a different reason — mixed Salamence frequently lures in and chips Flying-types and Gengar, which prevent Heracross from sweeping. Generally, Fighting-types like Heracross, Hariyama, and Breloom benefit from Salamence luring in their checks and tend to do well against teams that wall Salamence with Milotic, defensive Suicune, or defensive Starmie.
Snorlax checks common special attackers that Salamence struggles against such as Starmie, Zapdos, and Jolteon. It also pressures mixed Salamence's walls—Milotic, defensive Starmie, Blissey, Porygon2—and can help put Skarmory and Metagross in KO range of Fire Blast with its coverage and Self-Destruct. Salamence can switch into Heracross and Breloom, which take advantage of Snorlax. Spikes support from Pokemon such as Skarmory, Forretress, and Cloyster can help put Pokemon such as Blissey, Tyranitar, and Swampert in KO range of Salamence's coverage moves. Spikes can also greatly reduce the need for prediction. In return, Salamence can give Spikes setters support against Fighting-types and be a strong, fast cleaner. Defensive Jirachi can provide mixed Salamence with Wish support while Salamence pressures its checks—Swampert, Tyranitar, Metagross, and Snorlax—with its coverage moves. In some matchups, Jirachi will need to predict moves and switch-ins like Earthquake and Celebi to pass Wish to Salamence. Tyranitar's summoned sand is important for retaining chip damage on bulkier Pokemon such as Porygon2 and Blissey so Brick Break 2HKOes them. Additionally, sand preserves damage on checks like Zapdos and Gengar.