http://www.smogon.com/dp/pokemon/mesprit
Surprisingly Mesprit has an OU Trick Room analysis but not an UU one, so we might as well fix that.
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[SET]
name: UU Trick Room
move 1: Trick Room
move 2: Thunderbolt
move 3: Ice Beam
move 4: Psychic / U-turn
item: Expert Belt / Leftovers
nature: Quiet
evs: 252 HP / 4 Def / 252 SpA
ivs: 30 Atk / 0 Spe
[SET COMMENTS]
<p>With great defenses and a Speed stat of 148, Mesprit is a natural candidate for the role of setting up Trick Room. However, what really sets Mesprit apart from other Trick Room users, such as Uxie, is its ability to sweep under this effect as well. While Mesprit performs better on teams completely based around Trick Room, as it's is durable enough to set it up multiple times throughout the match, it can be used on all kinds of teams in need of a defensive pivot and mid- to late-game sweeper.</p>
<p>Ice Beam and Thunderbolt are the crux of this set, creating the infamous BoltBeam combo, which hits a good part of the metagame for super effective damage and is only resisted by Magneton, Lanturn, and Shedinja in UU. Psychic rounds off this set’s coverage as a solid STAB move that hits Poison- and Fighting-types for super effective damage while also being a great weapon against Pokemon that are hit for neutral damage by the aforementioned BoltBeam combination, such as Rotom and Arcanine. However, because this set does a very good job at supporting other teammates, one can forgo Psychic and use U-turn in order to allow Mesprit to act as a scout and help other sweepers come in unscathed.</p>
[ADDITIONAL COMMENTS]
<p>Despite the EVs on this set being straightforward, they can be tailored according to specific team needs. If Mesprit is running U-turn, an EV spread of 252 HP / 4 SpA / 252 Spe with a Timid nature is advisable, as it allows Mesprit to move after a significant amount of its opponents under Trick Room's effects; this enables one of its teammates to come in unharmed. Running a more defensive spread is yet another option if one wants Mesprit to stay around a bit longer to support its team, but that job is usually better left to Uxie, who has much higher defensive stats and superior Speed to abuse U-turn. Regarding the item of choice, Expert Belt is the preferred option, as it takes full advantage of Mesprit’s amazing super effective coverage without compromising its bulk like Life Orb would. Leftovers is a good alternative, especially if Mesprit’s main focus is support, where the added longevity is appreciated.</p>
<p>This set is stopped cold by the premier special walls of the tier, Registeel and Chansey, as well as specially defensive Spiritomb and Arcanine. As such, one should pair Mesprit with Pokemon that can easily get past the aforementioned threats. Marowak and Rhyperior are great choices for that role, as Trick Room rectifies their awful Speed stats, allowing them to have a much easier time sweeping. Dugtrio is another good option, as it can trap and KO most of the above Pokemon; however, one should be careful about using the two of them in conjunction, as Trick Room severely hampers Dugtrio’s main perk, its Speed. If Mesprit is used as a self-sustaining sweeper, Omastar and Cloyster are great options for partners, as they can provide Mesprit with Spikes support, the effectiveness of which is further enhanced by the fact that most of the pixie’s counters are grounded.</p>
