On def slowbro sets with twave you can give it 24 speed EVs to outspeed paralyzed m-lopunny. This helps tremendously when you're dealing with the PuP Encore set which I've seen a few times.
VVV EDIT: I disagree actually, because being able to safely twave after switching into any Mega Lopunny is much better than forfeiting all momentum by going for Slack Off. It helps a lot in general, not just against the encore set.
Let's say the opponent has a Latias, which is a really common partner for Mega Lopunny. Latias is also a common switch-in to slowbro when the opponent is looking for an opportunity to clear hazards. If you're not running 24 extra speed EVs on a twave set, you're putting yourself at risk of getting 3HKO'd if you choose to paralyze the lopunny before using Slack Off. However if you use Slack Off and the opponent switches directly to Latias, you've completely wasted a turn that you could have used to cripple Latias.
VVV EDIT: I disagree actually, because being able to safely twave after switching into any Mega Lopunny is much better than forfeiting all momentum by going for Slack Off. It helps a lot in general, not just against the encore set.
Let's say the opponent has a Latias, which is a really common partner for Mega Lopunny. Latias is also a common switch-in to slowbro when the opponent is looking for an opportunity to clear hazards. If you're not running 24 extra speed EVs on a twave set, you're putting yourself at risk of getting 3HKO'd if you choose to paralyze the lopunny before using Slack Off. However if you use Slack Off and the opponent switches directly to Latias, you've completely wasted a turn that you could have used to cripple Latias.
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