Well, since I normally lead with Spiritomb, lead Wobbuffet does nothing to me. Spiritomb pursues the switching Wobbuffet for ~36-43%, then I just wait for Wobbuffet to come back in. Unless I can predict and switch in a U-turn user, then I'll hit Wobbuffet as hard as I can. If my Pokemon is knocked out, then Spiritomb comes in to Pursuit FTW.
If Wobbuffet isn't the lead, once it switches in, hit it hard, revenge-kill with Pursuit, and job done.
There's not a whole lot that you can do in that situation without prediction. Just don't allow yourself to give Wobbuffet more than one kill.