Combined a few sets to try a make a decent smeargle lead that can pick up a kill while setting up for the team, came up with this, probably not the most original thing ever, but shows Smeargle isn't just a BP whore:
Smeargle @ Focus Sash
Endeavor Lead
-Spore
-Substitute
-Stealth Rock
-Endeavor
EVs - 96HP, 120Def, 252Speed, 40Sp.Def
The idea is to come in and Spore on the first turn, because even if the opposing pokemon is faster than you, Smeargle will hang on with Focus Sash. The only time I switch out is when I expect a Status from something faster than me. Anyway, once the opponent is sleeping Smeargle will be in one of two states, the most common being that Smeargle is on Full HP and the Opponent is sleeping. If so, I sub up. In this turn, the opponent normally switches, ready to start beating down Smeargle's sub. If again, Smeargle is the faster of the two, I Stealth Rock, and if not, I use Substitute again, and carry on subbing while the opponent attacks, all the way down to one HP, when I endeavor, bringing the opponent down to 1% health with me. Once Smeargle is finally down, the opponent is left with a Poké on 1% (prime bait for a Scizor with Pursuit and Bullet Punch) and another sleeping poke.
If Smeargle has been damaged first turn and has enough health to use Sub, I will. However, if Smeargle is left on 1% health, I endeavor, either hitting the lead poke down to 1% and sleeping, or hitting the switch in down to 1%. However, if so, Stealth Rock will not be set up, and so this is advised to be used alongside a Spiker of some sort, to provide backup passive damage.
You guys like? :)