This has been my favorite UU lead to use, so I thought I'd write up a Peer Edit. I'm not sure if it really needs a Peer Edit, but I thought I'd post it all the same. I originally had this with Stealth Rocks, and decided to throw on Toxic Spikes almost as an afterthought (Toxic Spikes probably deserves its own set though, so maybe this should just be "Stealth Rock Lead")
http://www.smogon.com/dp/pokemon/nidoqueen
[SET]
name: Support Lead
move 1: Stealth Rock / Toxic Spikes
move 2: Taunt
move 3: Earth Power
move 4: Ice Beam
item: Lum Berry
ability: Poison Point
evs: 252 HP / 200 Def / 12 SpD / 44 Spe
nature: Bold
[SET COMMENTS]
<p>With Taunt and her respectable bulk, Nidoqueen can take on the majority of common UU leads to set up Stealth Rock or Toxic Spikes, depending on your team's needs. Taunt and Lum Berry beats most sleep leads, such as Venusaur and Persian. Ice Beam and Earth Power get super-effective coverage against Steelix, Venusaur, Electrode, and Ninetales, among other common leads. Most leads are incapable of OHKOing her with their standard sets, giving her ample time to set up Stealth Rocks or Toxic Spikes, Taunt to prevent their set-ups, or attack them outright.<p/>
<p>The 44 Speed EVs allow Nidoqueen to outspeed 4 Speed EV Venusaur. 200 Defense EVs ensures that Nidoqueen will never be 2HKOed by Primeape's Earthquake (assuming Adamant nature, 252 Attack EVs, holding a Choice Scarf), and the 12 Special Defense EVs ensure Nidoqueen will always avoid a 2HKO from Venusaur's Leaf Storm (assuming Timid Nature, 252 Special Attack EVs, holding a Choice Scarf).</p>
<p>How this is played and what move you choose for moveslot 1 depends largely on your team. If you're using this on a more offensively-leaned team, going with Stealth Rocks is the preferred option. If you're just setting up for your hard-hitters, Nidoqueen is basically played as a scout, Taunting things and attacking things until she goes down, in order to send in a threatening sweeper for free. This way, you can gain information about your opponent's team and can set up Stealth Rocks, which can give you the upper hand quickly and allow you to control the pace of the battle. However, if you're using a more balanced team, using Stealth Rocks may be preferable because Toxic Spikes is not a very accessible move in UU, unlike Stealth Rocks, which the top three most common UU Pokemon are capable of using. If this is being used on a balanced team, it's better to play conservatively so she has more opportunities to switch in later.</p>
http://www.smogon.com/dp/pokemon/nidoqueen
[SET]
name: Support Lead
move 1: Stealth Rock / Toxic Spikes
move 2: Taunt
move 3: Earth Power
move 4: Ice Beam
item: Lum Berry
ability: Poison Point
evs: 252 HP / 200 Def / 12 SpD / 44 Spe
nature: Bold
[SET COMMENTS]
<p>With Taunt and her respectable bulk, Nidoqueen can take on the majority of common UU leads to set up Stealth Rock or Toxic Spikes, depending on your team's needs. Taunt and Lum Berry beats most sleep leads, such as Venusaur and Persian. Ice Beam and Earth Power get super-effective coverage against Steelix, Venusaur, Electrode, and Ninetales, among other common leads. Most leads are incapable of OHKOing her with their standard sets, giving her ample time to set up Stealth Rocks or Toxic Spikes, Taunt to prevent their set-ups, or attack them outright.<p/>
<p>The 44 Speed EVs allow Nidoqueen to outspeed 4 Speed EV Venusaur. 200 Defense EVs ensures that Nidoqueen will never be 2HKOed by Primeape's Earthquake (assuming Adamant nature, 252 Attack EVs, holding a Choice Scarf), and the 12 Special Defense EVs ensure Nidoqueen will always avoid a 2HKO from Venusaur's Leaf Storm (assuming Timid Nature, 252 Special Attack EVs, holding a Choice Scarf).</p>
<p>How this is played and what move you choose for moveslot 1 depends largely on your team. If you're using this on a more offensively-leaned team, going with Stealth Rocks is the preferred option. If you're just setting up for your hard-hitters, Nidoqueen is basically played as a scout, Taunting things and attacking things until she goes down, in order to send in a threatening sweeper for free. This way, you can gain information about your opponent's team and can set up Stealth Rocks, which can give you the upper hand quickly and allow you to control the pace of the battle. However, if you're using a more balanced team, using Stealth Rocks may be preferable because Toxic Spikes is not a very accessible move in UU, unlike Stealth Rocks, which the top three most common UU Pokemon are capable of using. If this is being used on a balanced team, it's better to play conservatively so she has more opportunities to switch in later.</p>