I ahve tried it before and I have to honestly say, Toxic Spikes are useless. Why? Well the teams I see now are usually along the lines of:
2 flying types/levitators, steel type, 2 poison types, cleric. Or if you want specific, most teams are along the lines of:
Swellow, Steelix, Nidoking, Toxicroak, Meganium, Rotom.
And there are other threats such as Guts Raticate, Clefable who wont mind it, Venomoth, Drapion, Drifblim, Altaria, ect. Toxic Spikes just don't seem effective to me in UU play so I would highly discourage you from using them.