JRT, I had some issues with wondercard frames, and the only thing I could really recommend is possibly releasing a runner if you have any left. For whatever reason, for me it seemed to give me much more consistent results, whereas without a runner the frame did not really seem to end up where I wanted it, and was different each time. Also just try exiting the building and re-saving. Don't know if it actually works, but I did that also while releasing my runner.
Misdreavus, yes that is basically what you have to do. Emloop makes wondercards much easier, as you can hit a higher delay and have extremely low frames (the ones I did had all frames <50). This makes it much less time consuming for each reset. And fluking the nature is a huge pain, especially if you're only going for one certain nature.