I really think that this might be one of the most underrated threats (and bulky win conditions) out there. I disagree that regular calm mind slowbro can take 'the same' place but without taking up the mega slot. We have to count that regular Slowbro needs to be full defense, because if you invest a lot in spdef on the purpose of being stopped harder by things like his checks after one calm mind (slowbro mostly needs this), you will end up in being stopped by physical attackers, and you can not switch in some powerful physical attacks, unlike classic full def slowbro. Sure, you lose regenerator which is a very important ability for Slowbro; because of this, you need to know when it's the moment to mega evolve Slowbro (to keep your momentum), which in my opinion compensates the loss of Regenerator with his insane capability. While you will have a kind of disadvantage in terms of bulk when you keep normal Slowbro with Mega (SpDef) into his normal form to keep regenerator, Mega Slowbro can be a pain in the ass to deal with. His insane bulk allows to deal with both physical and special attackers. You will have over 400 points of physical defense with Mega Slowbro, even if you invest a lot in spdef. You will end up having a stupid, lazy and ignorant pokèmon which is impossible to even break his armor to kick his ass, even after one calm mind. Shell Armor will keep a safe spam of slack off as you don't fear critical hits, you can also choose to modify your Evs according to your weaknesses. Like slowbro, mega slowbro doesn't appreciate status, especially bad poison. Even if you try to status mega slowbro, it won't be enough to stop him from slaughter the opposing pokes by dint of boosted Scalds and Psyshocks. So even if you wear down mega slowbro thanks to status, or by other stuff, he has probably already done his task: destroy the opponent's team, or at least, a great portion. He has flaws, mostly due to the loss of regenerator, difficulty to recover if there are hazards and sometimes the obligation of sacking it, and these flaws might surely let Mega Slowbro unable to satisfy A+ or S rank even with these incredible capabilities, but nonetheless, it's surely worth for A rank.
56 Atk Life Orb Teravolt Kyurem-B Fusion Bolt vs. 252 HP / 28+ Def Mega Slowbro: 164-195 (41.6 - 49.4%) -- guaranteed 3HKO (Mega Slowbro can pp stall his fusion bolt with Slack off btw)
252 Atk Tough Claws Mega Metagross Thunder Punch vs. 252 HP / 28+ Def Mega Slowbro: 126-150 (31.9 - 38%) -- 95.6% chance to 3HKO
0 SpA Tough Claws Mega Metagross Grass Knot (100 BP) vs. +1 252 HP / 220 SpD Mega Slowbro: 126-150 (31.9 - 38%) -- 95.6% chance to 3HKO
+1 192+ Atk Pixilate Mega Altaria Return vs. 252 HP / 28+ Def Mega Slowbro: 162-192 (41.1 - 48.7%) -- guaranteed 3HKO
252+ SpA Life Orb Sheer Force Landorus Earth Power vs. +1 252 HP / 220 SpD Mega Slowbro: 157-187 (39.8 - 47.4%) -- guaranteed 3HKO
252+ Atk Landorus-T Earthquake vs. 252 HP / 28+ Def Mega Slowbro: 103-123 (26.1 - 31.2%) -- guaranteed 4HKO
+2 252 Atk Sharp Beak Talonflame Brave Bird vs. 252 HP / 28+ Def Mega Slowbro: 183-216 (46.4 - 54.8%) -- 62.1% chance to 2HKO
252 Atk Tyranitar Crunch vs. 252 HP / 28+ Def Mega Slowbro: 144-170 (36.5 - 43.1%) -- guaranteed 3HKO after sandstorm damage
252 Atk Aerilate Mega Pinsir Return vs. 252 HP / 28+ Def Mega Slowbro: 133-157 (33.7 - 39.8%) -- guaranteed 3HKO
252+ Atk Huge Power Diggersby Return vs. 252 HP / 28+ Def Mega Slowbro: 115-136 (29.1 - 34.5%) -- 6.5% chance to 3HKO
252 Atk Life Orb Weavile Knock Off vs. 252 HP / 28+ Def Mega Slowbro: 140-166 (35.5 - 42.1%) -- guaranteed 3HKO
252 Atk Tough Claws Mega Metagross Thunder Punch vs. 252 HP / 28+ Def Mega Slowbro: 126-150 (31.9 - 38%) -- 95.6% chance to 3HKO
0 SpA Tough Claws Mega Metagross Grass Knot (100 BP) vs. +1 252 HP / 220 SpD Mega Slowbro: 126-150 (31.9 - 38%) -- 95.6% chance to 3HKO
+1 192+ Atk Pixilate Mega Altaria Return vs. 252 HP / 28+ Def Mega Slowbro: 162-192 (41.1 - 48.7%) -- guaranteed 3HKO
252+ SpA Life Orb Sheer Force Landorus Earth Power vs. +1 252 HP / 220 SpD Mega Slowbro: 157-187 (39.8 - 47.4%) -- guaranteed 3HKO
252+ Atk Landorus-T Earthquake vs. 252 HP / 28+ Def Mega Slowbro: 103-123 (26.1 - 31.2%) -- guaranteed 4HKO
+2 252 Atk Sharp Beak Talonflame Brave Bird vs. 252 HP / 28+ Def Mega Slowbro: 183-216 (46.4 - 54.8%) -- 62.1% chance to 2HKO
252 Atk Tyranitar Crunch vs. 252 HP / 28+ Def Mega Slowbro: 144-170 (36.5 - 43.1%) -- guaranteed 3HKO after sandstorm damage
252 Atk Aerilate Mega Pinsir Return vs. 252 HP / 28+ Def Mega Slowbro: 133-157 (33.7 - 39.8%) -- guaranteed 3HKO
252+ Atk Huge Power Diggersby Return vs. 252 HP / 28+ Def Mega Slowbro: 115-136 (29.1 - 34.5%) -- 6.5% chance to 3HKO
252 Atk Life Orb Weavile Knock Off vs. 252 HP / 28+ Def Mega Slowbro: 140-166 (35.5 - 42.1%) -- guaranteed 3HKO
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