One thing I've been having lots of fun with as of late is Sub Typhlosion. Generally overshadowed by things like Moltres, Houndoom, and even Charizard, Typhlosion still has its own little niche mainly in the form of its ability, Blaze. Charizard gets it but 4x weak to sr hurts a lot more then 2x does. I've been running a set of:
Typhlosion@Life Orb
252 SpA / 252 Spe / 4 Def - Timid
~ Substitute
~ Fire Blast
~ Hidden Power [Water]
~ Toxic
Sub also does a nice job of blocking Sucker Punches, Twaves, scouting, and beating Dugtrio switches. Fire Blast, especially in Blaze, rips things to shreds. I've been Toxicing Milotic as it switches in (87.5%, toxic cancels lefties first turn) then sub stalling (81.25, 68.75, 50% after lefties) and finally hitting it for about 38% with a Blaze LO Fire Blast. This leaves so much stuff open for things walled mainly by Milo. (Moltres, Houndoom, Feraligatr, so on) If something else takes out Milotic first, so be it as Typhlosion uses a great 100 base speed to beat most of the metagame with STAB Fire Blasts and great secondary coverage in HP Water.