Mkay, let's get this started:
New England at Detroit: As much as I would like the Lions to pull a Browns here, I don't see it happening.
New Orleans at Dallas: Fuck Dallas, go back into the hole you guys so willingly dug yourselves into.
Cincinnati at New York Jets: After they surrendered what, 30+ straight unanswered points, I don't think I'll pick the Bengals to win ever...
Minnesota at Washington: McNabb =/= Favre, and I doubt a coaching change will accomplish much, other than maybe there being less lockeroom stress. Still, considering the Redskin's piss-poor defense, bit of a risky pick.
Carolina at Cleveland: Here we will get to learn why McCoy is a better pick than Clausen...unless McCoy is definitely out (and Clausen as well). So yeah...
Tennessee at Houston: To think both teams started out so promising this season...anyways, Houston at least has their QB, while Titans are flat-lining rapidly. If they can at least limit CJ2k, Texans have this in the bag by forcing Titans to throw.
Jacksonville at New York Giants: As hot as Jacksonville is, Giants should recover quickly from their loss to the Eagles to show why they're better.
Pittsburgh at Buffaro: Lol Buffaro...well, not really lol, they can get nasty if the opponent lets them. However, I expect the Steelers to not allow 30+ unanswered points in the last half.
Green Bay at Atlanta: I really don't feel safe picking this since fucking Ryan is nearly unbeatable at home, but I'm going for the upset here with the Packers, who I feel is a more solid team overall (especially when not committing stupid penaltiess).
Kansas City at Seattle: Seattle needs to keep losing, and the Chiefs need to keep winning. Easy enough for both teams to accomplish.
Miami at Oakland: Lol Dolphins, I'm scared to imagine what will happen if their QBs keep getting KOed with injuries.
St. Louis at Denver: Need Rams to lose more, plus they're bad on the road. Denver is crap also, but I want them to win in this case.
Tampa Bay at Baltimore: Buccaneers have pulled some crazy last second comebacks, but I'm sticking with the Ravens and their stout defense to limit Freeman.
Philadelphia at Chicago: Going with Vick (MVP) over Cutler in this, he's a little more...reliable. And Kolb is always there if something should happen to Vick.
San Diego at Indianapolis: Another pick I'm leery of making, since Chagers seem to be making their usual late season drive to the playoffs, and the Colts are fairly depleted. But I'm betting Manning will work some magic at home to find a win.
San Francisco at Arizona: Fuck Cardinals, go NINERS! You CANNOT afford to lose this game.